The effect of Pelargonium odoratissimum extract on some patients with diabetes
DOI:
https://doi.org/10.58916/jhas.v9i5.562Keywords:
diabetes, glucose level, glycated hemoglobin, Insulin, Pelargonium odoratissimumAbstract
Diabetes mellitus is a chronic disease that persists with an individual throughout their life, leading to numerous complications and negatively affecting all body organs, starting from the skin and ending with the bones. Passing through all tissues and organs, including the heart and blood vessels. It also affects the patient or their relatives economically. The trend towards alternative medicine has become less harmful to human health and less costly due to the availability of plants and the low cost of extracting raw materials from them. This study aimed to determine the effect of the Pelargonium odoratissimum plant on glucose levels and glycosylated hemoglobin in diabetic patients. The study was conducted on 35 volunteer participants, including 20 diabetic patients and 15 healthy individuals. Where the extract of the plant was administered at a dose of 50 ml daily for three months to investigate the plant's effect and compare it with a reference. Blood samples were collected from all individuals before using the extract and after each month during the study period to measure blood glucose levels and glycated hemoglobin levels after three months. The results showed a significant decrease in blood glucose levels and glycosylated hemoglobin in the patients after treatment with the extract.
Conclusion: The concentrated Pelargonium odoratissimum extract has a clear blood sugar-lowering effect; however, it is necessary to delve deeper and conduct more research and new scientific studies to confirm the obtained results, particularly the isolation of the active substance from the plant.
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Arabic References:
Al-Aghwani, Wael (2014). Investigating the effect of the fragrant plant on diabetic rats and comparing it with oral hypoglycemic agents, Damascus University Journal for Health Sciences - Volume Thirty - Issue One.
Belos, Rudy. (2013) Diabetes, Edition 1, Translators (Hanadi Mazboudi) - King Fahd National Library. Riyadh, Saudi Arabia, Author's House.
Al-Hamid, Muhammad bin Saad. (2008) Diabetes, its causes, complications and treatment - King Fahd National Library. Riyadh, Saudi Arabia.
6- Foreign References
Almundarij, T. I., Zaki, A. K. A., Albarrak, S. M., Alharbi, Y. M., Almuzaini, S. A., & Abo-Aziza, F. A. (2020). Evaluation of the Anti-diabetic Activities of Colored Rice Varieties in Streptozotocin-Induced Diabetic Rats. Systematic Reviews in Pharmacy, 11(11), 1424-1433.
Astrid Petersmann, Müller-Wieland, D., Müller, U. A., Landgraf, R., Nauck, M., Freckmann, G., Heinemann, L., & Schleicher, E. (2019). Definition , Classification and Diagnosis of Diabetes Mellitus * Authors Definition of Diabetes Mellitus Diagnostic Criteria of Diabetes Mellitus. German Diabetes Association, 127(Suppl 1), 51–57.
Bailes, B. K. (2002). Diabetes mellitus and its chronic complications. Aorn J., 76:266-282.
Benny, K. and Adithan,A.C. (2000). Review of endocrine pharmacology.Indian. J. pharmacology, 32: 67-80.
Boukhris, Maher ; Bouaziz, Mohamed ; Feki, Ines et al., (2012). "Hypoglycemic and antioxidant effects of leaf essential oil of Pelargonium graveolens L’Hér. in alloxan induced diabetic rats", Lipids in Health and Diseases, Folder 81, Page 11. Edited.
Celi, ,Diana ; Quiroz, Evelyn ; Beltrán-Noboa, Andrea ; Machado, António ; Tejera , Eduardo ; Fernandez-Soto, Paulina (2024). A chemical analysis of the Pelargonium species: P. odoratissimum, P. graveolens, and P. zonale identifies secondary metabolites with activity against gram-positive bacteria with multidrug-resistance. PLoS ONE 19(7). https://doi. org/10.1371/journal.pone.0306637.
Chelghoum, M., Khitri, W., Bouzid, S., & Lakermi, A. (2021). New trends in the use of medicinal plants by Algerian diabetic patients, considerations of herb-drug interactions. Journal of ethnopharmacology, 274, 113984.
Chen, T., Gao, J., Xiang, P., Chen, Y., Ji, J., Xie, P., Wu, H., Xiao, W., Wei, Y., Wang, S., Lan, L., Ji, H., & Yan, T. (2015). Protective effect of platycodin D on liver injury in alloxan-induced diabetic mice via regulation of Treg/Th17 balance. International Immunopharmacology, 26(2), 338–348.
Cock, I. E., Orchard, A., Booi, L., & van Vuuren, S. F. (2024). Southern African traditional herbal medicinal plants used to treat cardiovascular disease and related medical conditions: Traditional use and scientific evidence. South African Journal of Botany, 173, 1-18.
Crespilho, D.M; Leme, J.A.C.A; Mello, M.A.R. and Luciano, E. (2011). Effects of physical training on the immune system in diabetic rats .Int.J.Diab. Ctries., 30 :233-240.
Daisy, P ; Santosh, K.and Rajathi, M. (2009). Antihyperglycemic and Antihyperlipidemic effects of Clitoria ternatea Linn. in alloxan-induced diabetic rats. Afr. J. Microbiol. Res., 3 (5) , 287-291.
Dumlupinar, B., Celik, D. D., Karatoprak, G. Ş., & Gürer, Ü. S. (2022). Synergy between Pelargonium endlicherianum essential oil and conventional antibiotics against Neisseria meningitidis and Haemophilus influenzae. South African Journal of Botany, 146, 243-253.
George Krucik (2016), "Herbs and Supplements for Diabetes" www.healthline.com.
Holman N, Young B, Gadsby R. (2015). Current prevalence of Type 1 and Type 2 diabetes in adults and children in the UK. Diabet Med. Sep;32 (9):1119–20. doi:10.1111/dme.12791.
Hsouna, A. B., Chahdoura, H., Mekinić, I. G., Maisto, M., Kukula-Koch, W., Zeljković, S. Ć., ... & Kačániová, M. (2024). A comprehensive review on traditional uses, chemical composition, pharmacological effects and applications in the food industry of Pelargonium odoratissimum (L.) L'Hér. in comparison to other Pelargonium spp. South African journal of botany, 174, 456-467.
Jon Johnson (2019), "Seven herbs and supplements for type 2 diabetes" www.medicalnewstoday.com.
Lachin, T. and Reza, H. (2012). Anti-Diabetic Effect of Cherries in Alloxan Induced Diabetic Rats. Patents on Endocrine, Metabolic & Immune Drug Discovery Iran, 6(n/a), 67–72.
Mari, LIS-BALCHIN and Gerhild, ROTH. (2000). Composition of the essential oils of Pelargonium odoratissimum, P. exstipulatum, and P. x fragrans (Geraniaceae) and their bioactivity. Flavour and fragrance, 15, no6, pp. 391-394.
Mativandlela, S.P.N. ; Lall, N. ; Meyer, J.J.M. (2006). Antibacterial, antifungal and antitubercular activity of (the roots of) Pelargonium reniforme (CURT) and Pelargonium sidoides (DC) (Geraniaceae) root extracts. South African Journal of Botany 72 , 232 – 237.
Paniagua-Zambrana, N. Y., Bussmann, R. W., & Romero, C. (2020). Pelargonium odoratissimum (L.) L’Hér. Pelargonium roseum Willd. Pelargonium zonale (L.) L’Hér. Geraniaceae. In Ethnobotany of the Andes (pp. 1385-1390). Cham: Springer International Publishing.
Saeedi P, Petersohn I, Salpea P, Malanda B, Karuranga S, Unwin N, et al. (2019) Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas. Diabetes Res Clin Pract. Nov;157:107843. doi:10.1016/j.diabres.2019.107843.
Singh, A. & Gupta, R. (2020). "Anti-diabetic effects of Tephrosia, villosa extracts in streptozotocin-induced diabetic rats". Journal of Natural Products.
Steven, E., Nissen, M.D. and Kathy Wolski, M.P.H. (2007). Effect of rosiglitazone on the risk of ryocardial infarction and death from cardiovascular causes. The New England Journal of Medicin, 356(n/a), 2457–71.
Zimmet, P., Alberti, K.G. and Shaw, J. (2001). Global and societal implications of the diabetes epidemic. Nature, 414(6865), 782–7.
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