THE RADIATION EFFECT ON BLOOD CELLS IN CANCER PATIENTS WHO HAVE UNDERGONE EXTERNAL RADIATION THERAPY- ANALYTICAL STUDY

Nureddin. A. S. Musa; Samia. A. Alkdrawe

doi:10.58916/jhas.v10i2.814

THE RADIATION EFFECT ON BLOOD CELLS IN CANCER PATIENTS WHO HAVE UNDERGONE EXTERNAL RADIATION THERAPY- ANALYTICAL STUDY

Nureddin. A. S. Musa General Department, Faculty of Biotechnology, University of Jfara, Jfara, Libya
Samia. A. Alkdrawe Department of Medical Laboratories, Faculty of Medical Technology, University of Jfara, Jfara, Libya

https://doi.org/10.58916/jhas.v10i2.814

منشور: 2025-06-04

تحميل pdf

الملخص

Normal leukocytes count ranges from 4500-11000, Platelets 150,000-400,000/mm3 and Hemoglobin level male: 13.5-17.5 g/dL, female: 12.0-16.0 g/dL. External beam radiation therapy is a treatment using high-energy ionizing radiation is part of cancer treatment methods to control and kill malignant cells at the treatment site. However, normal cells and cancer cells are affected at the same time, the effect depends on the sensitivity of the Cells as well as the value of the dose deposited to the area. This study is aimed at assessing only changes in WBCs, Plts and Hgb level. PATIENTS AND METHODS: Forty-two patients from the University Hospital radiotherapy department in Tripoli, Libya, were included in this study from April to August 2024. The information related to the study was collected from the archive unit of the department after approval to conduct the study. RESULTS: Out of the 42 patients, 26 (61.90%) females and 16(38.1%) males, the median age was 51.4years the age group has diversified (17 to 82) years. According to the treatment sites we classified them into eight groups the most common cancer was breast cancer accounting for 20 (47.6%), 6(14.28%) of cases were head and neck, 4(9.52%) larynx cancers, 4(9.52%) lymphoma cancer, 2(4.76%) lung, 3(7.14%) prostate, 2(4.76%) cervix and 1(2.38%) rectum. We found a statistically significant (P<0.10) reduction in total (WBCs) count, Plts counts and Hgb level when compared the results of Pre RT to Post RT. CONCLUSION: Leukocytes, platelets and hemoglobin level, are the main hematological indicators that predict the response rate to treatment, severity of the disease. The effectiveness and progress of radiation therapy can be estimated in this way.

الكلمات المفتاحية: Effect radiotherapy criteria hematology cancer patients

كيفية الاقتباس

Nureddin. A. S. Musa, & Samia. A. Alkdrawe. (2025). THE RADIATION EFFECT ON BLOOD CELLS IN CANCER PATIENTS WHO HAVE UNDERGONE EXTERNAL RADIATION THERAPY- ANALYTICAL STUDY. مجلة جامعة بني وليد للعلوم الإنسانية والتطبيقية, 10(2), 573-581. https://doi.org/10.58916/jhas.v10i2.814

تنزيل الاقتباسات

إصدار

مجلد 10 عدد 2 (2025): المجلد العاشر ، العدد الثاني 2025

القسم

Article

الرخصة

هذا العمل مرخص بموجب Creative Commons Attribution 4.0 International License.

السيرة الشخصية للمؤلف

Nureddin. A. S. Musa، General Department, Faculty of Biotechnology, University of Jfara, Jfara, Libya

CURRICLUM VITAE

TO WHOM IT MAY CONCERN

1

PERSONAL INFORMATION:-

·         Name: Nureddin Ahmed.S. Musa

·         Nationality: Libyan

·         Marital Status: Married

·         Address: Tripoli - Libya

-         Contact points: Phone:- 0915194767, 0925194767

-         Email:-nureddine2001@yahoo.com., nureddin.a.s.musa@aju.edu.ly

-         Affiliation: College of Biotechnologies, Aljfara University- Libya

2

EDUCATIONAL PROFILE:-

·         BSc degree College of medical technology Radio-diagnostic and therapeutic year 1992.

·         PG. Certificate in Radiation therapy, year 2001.

·         MSc degree Medical Physics year 2017.

·         PhD degree Medical Physics year 2021.

3

CLINICAL EXPERIENCE PROFILE:-

·         Certificate ( Quality Assurance and Quality control procedures for radiology) year1997 Kenya - IAEA.

·         Certificate (Regulatory authorization and inspection of Radiation Sources in medical practices) 2003 Tripoli – IAEA.

·         Certificate (Radiation therapy practice, Dosimetry) 2006., Cancer institute in Morocco- IAEA.

·         Certificate (Medical Physics dosimetry and QA Radiation Therapy 2010., IAEA cancer institute in Morocco.

·         Certificate (Applications of radioisotopes, Radiation Protection and Radiation Safety) Middle Eastern Regional Radioisotope Center for the Arab Countries year 2012.

4

FUNCTIONAL TAKS:-

·         Member of Radiation therapy department since 1995 - 2012 as Radiotherapist with full responsibility.

·         Member of Radiation Protection Committee 2012 - 2018, Tripoli Central Hospital.

·         Member of European Society of Radiology since 2012- 2024.

·         Head of National Project, Cooperation with the International Atomic Energy Agency, LIB6009 ( 2014-2017).

·         Member of Teaching staff, Undergraduate, Graduate- Libyan Universities since 2018- 2025.

5

PUBLICATIONS:-

·         Seven Papers has been Published since 2016 -2024.

6

PERSONAL SKILLS

·         Organization, management and leadership.

·         Time Management.

·         Effective communication with others.

·         The use of computer applications ( statistical analysis).

You're sincerely

المراجع

. Begg AC, Stewart FA, Vens C. Strategies To Improve Radiotherapy With Targeted Drugs. National reviews. Cancer. 2011 April;11(4):239–53.

. Barnett GC, West CML, Dunning AM, Elliott RM, Coles CE, Pharoah PDP, et al. Normal Tissue Reactions to Radiotherapy: Towards Tailoring Treatment Dose by Genotype. Vol. 9, Nature reviews. Cancer. England; 2009. p. 134– 42.

. Baskar R, Lee KA, Yeo R, Yeoh KW. Cancer and Radiation Therapy: Current Advances and Future Directions. International Journal of Medical Sciences. 2012;9(3):193–9.

. El-Shanshoury H, El-Shanshoury G, Abaza A. Evaluation of Low Dose Ionizing Radiation Effect on Some Blood Components in Animal Model. Journal of Radiation Research and Applied Sciences. 2016 Jul 1;9(3):282–93.

. AL-Dulaimi K, Chandran V, Banks J, TomeoReyes I, Nguyen K. Classification of White Blood Cell Types from Microscope Images: Techniques and Challenges. Microscopy Science: Last Approaches on Educational Programs and Applied Research. 2018;8:17–25.

. Kuter DJ. Managing Thrombocytopenia Associated With Cancer Chemotherapy [Internet]. [cited 2020 Feb 23]. Available from:

https://www.cancernetwork.com/oncologyjournal/managing-thrombocytopenia-associatedcancer-chemotherapy.

. Panawala L. What is the Function of Hemoglobin in the Human Body [Internet]. 2017 [cited 2020 Feb 28]. Available from: https://www.researchgate.net/publication/31384 1668_What_is_the_Function_of_Hemoglobin_i n_the_Human_Body.

. Zhang X, He Y, Xie X, Ji M, Ma X, Yu Z. Distribution of Hemoglobin and Prevalence of Anemia in 10 Ethnic Minorities in China. Medicine. 2017;96(50):e9286.

10.

. Yanazume S, Karakida N, Higashi R, Fukuda M, Togami S, Kamio M, et al. Tumor Bleeding Requiring Intervention and The Correlation with Anemia in Uterine Cervical Cancer for Definitive Radiotherapy. Japanese Journal of Clinical Oncology. 2018;48(10):892–9.

11.

. Thakur P, Seam RK, Gupta MK, Rastogi M, Gupta M, Bhattacharyya T, et al. Comparison of Effects of Hemoglobin Levels Upon Tumor Response Among Cervical Carcinoma Patients Undergoing Accelerated Hyperfractionated Radiotherapy Versus Cisplatin Chemoradiotherapy. Asian Pacific Journal of Cancer Prevention. 2015;16(10):4285–9.

12.

. Fajaria TD. Penurunan Jumlah Eritrosit, Leukosit, dan Trombosit pada Penderita Kanker Serviks Uteri Pasca Radioterapi [skripsi]. Surakarta (Indonesia): Universitas Sebelas Maret; 2012.

13.

. Nisa AK. Efek Radioterapi Terhadap Produksi Sel Darah Pada Penderita Ca Mammae Dan Ca Cervix [thesis]. Malang (Indonesia): Univeritas Brawijaya; 2014 [cited 2020 Feb 28]. Available from: http://repository.ub.ac.id/id/eprint/154000.

14.

. Ian RO, Sutapa GN, Sudarsana WB. Studi Standarisasi Radioterapi Cobalt-60 Terhadap Kuantitas Sel Darah Pada Penderita Kanker Serviks (Cancer Cervics) Di RSUP Sanglah Denpasar. Buletin Fisika. 2017;18(2):63-67.

15.

Ye L, Oei RW, Kong F, Xu T, Shen C, Wang X, et al. Prognostic values of hematological biomarkers in nasopharyngeal carcinoma patients treated with intensity-modulated radiotherapy. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies. 2018;275(5):1309-17.

16.

. Su Z, Mao YP, OuYang PY, Tang J, Xie FY. Initial Hyperleukocytosis and Neutrophilia in Nasopharyngeal Carcinoma: Incidence and Prognostic Impact. PloS one. 2015;10(9):e0136752.

17.

. Li X, Chang H, Tao Y, Wang X, Gao J, Zhang W, et al. Revalidation of a prognostic score model based on complete blood count for nasopharyngeal carcinoma through a prospective study. Chinese journal of cancer research=Chung-kuo yen cheng yen chiu. 2016;28(5):467-77.

18.

. Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell. 2010;140(6):883-99.

19.

. Chang H, Gao J, Xu BQ, Guo SP, Lu RB, Li G, et al. Hemoglobin, neutrophils to lymphocyte ratio and platelet count improve prognosis prediction of the TNM staging system in nasopharyngeal carcinoma: development and validation in 3,237 patients from a single institution. Clinical oncology. 2013;25(11):639-46.

20.

. Liu L-T, Chen Q-Y, Tang L-Q, Guo S-S, Guo L, Mo H-Y, et al. The Prognostic Value of Treatment-Related Lymphopenia in Nasopharyngeal Carcinoma Patients. Cancer Res Treat. 2018;50(1):19-29.

21.

. Hall S, Rudrawar S, Zunk M, Bernaitis N, Arora D, McDermott CM, et al. Protection against Radiotherapy-Induced Toxicity. Antioxidants. 2016;5(3).

22.

. Cox JD, Stetz J, Pajak TF. Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC). International journal of radiation oncology, biology, physics. 1995;31(5):1341-6.

23.

. Mornex F, Pavy JJ, Denekamp J, Bolla M. [Scoring system of late effects of radiations on normal tissues: the SOMA-LENT scale]. Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique. 1997;1(6):622-68.

24.

.Sacks El, Goris Ml, Glatstein E, et al: Bone marrow regeneration following large field radiation ,Cancer 42:1057-1065, 1978.

25.

. Sykes MP, Chu FCH, Savel H, et al: The effects of varing dosages of irradiation upon sterna marrow regeneration, Radiology 83:1087, 1964.

26.

. Sykes MP, Chu FCH, Wilkerson WG: Local bone marrow changes secondary to therapeutic irradiation, Radiology 75:919-924, 1960.

27.

. Groopman JE, Molina J-M, Scadden DT. Hematopoietic growth factors: biology and clinical applications. N Engl J Med 321, 1989, 1449-59.