Study the effect of smoking cigarettes on some blood coagulation tests and platelet counts for those attending Sebha Medical Hospital and Tsawa Rural Hospital
DOI:
https://doi.org/10.58916/jhas.v10i1.669Keywords:
Cigarette smoking,platelet count,Prothrombin time,Thromboplastin timeAbstract
Chronic cigarette smoking affects normal hemostasis by affecting coagulation pathways However., the effect of smoking intensity on the coagulation cascade remains unclear.
Cigarette smoking leads to a serious health problem and is considered one of the leading causes of death worldwide. It is estimated that at least 20% of all cancers today are attributable to smoking. This study was conducted to evaluate the effect of smoking on the platelet count and on the coagulation pathway and the change in prothrombin time (PT) and thromboplastin time (APTT), and to study the association between the duration of smoking with study variables.
Methods: This study was conducted for a group of men attending Sabha Medical Center and Tsawa Rural Hospital. Their number was 80 smokers and 60 non-smokers, and their age sranged between 25-65 years. Blood samples were taken from them to measure the variables under study after the questionnaire attached to the study was filled out.
Venous blood samples were drawn from them, and the blood samples taken were placed in tubes containing the anticoagulant Lithium Heparin in order to conduct a CBC analysis, and other tubes containing the anticoagulant sodium citrate to obtain plasma for conducting fluidity analyses. The platelet count, PT time, and APTT time were measured.
Results:The platelet count was significantly lower in smokers(225.85±.8750).
Compared to non-smokers(295.01±90.87)(P<0.05),the APTT time was significantly longer(35.00)±2.84in smokers compared to non-smokers(31.00)±4.48)(P<0.005),and the PT time was significantly longer(16.55)( 1.59)in smokers compared to non-smokers.
Pearson correlation analysis showed strong negative relationship between smoking duration and platelet count with smoking duration r = 0.007(P = -0.297).
Conculsion:
Chronic smokers tend to have lower platelet counts, lower PT time and APTT time in smokers compared to non-smokes, and research on the effect of smoking on platelets is still an important filed in research on the pathogenesis of acute thromoolism in smokers
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