Synthesis and Characterization of a Novel Schiff Base and its Complexes with Cobalt(II), Nickel(II), Copper(II), and Zinc(II): Spectroscopic Study and Evaluation of Biological Activity
الملخص
This study presents the synthesis and characterization of a novel Schiff base ligand, (Z)-4-((benzo[d]thiazol-2-ylimino)methyl)phenol (L1), derived from the condensation of 4-hydroxybenzaldehyde and 2-aminobenzothiazole. The ligand was used to prepare a series of transition metal complexes with Co(II), Ni(II), Cu(II), and Zn(II) in both Metal(M): Ligand (L1):1,10-Phenanthroline (phen) , and M: 2L1 stoichiometries. The ligand and complexes were characterized using various spectroscopic methods, including proton nuclear magnetic resonance spectroscopy (¹³C, ¹H-NMR) as well as infrared (FTIR) and ultraviolet spectroscopy(UV), in addition to melting point, accurate elemental analysis (CHNS), and atomic absorption.
Magnetic measurements and molar conductivity revealed that all complexes adopt an octahedral shape, while thermogravimetric analysis (TGA) indicated that the formed complexes are free of water. Biological studies showed that the prepared ligands and complexes possess moderate antibacterial activity against both Staphylococcus aureus (Gram-positive) and Pseudomonas aeruginosa (Gram-negative). The major fragmentation patterns in the mass spectrometry of the [Zn(L1)₂Cl₂] complex also supported its proposed structure.