Inhibitory effects for ligand (1,1- dimethyl -3-(thiazole -2-yl)-triazine) and some its complexes on Lactate dehydrogenase (LDH), and Creatine phosphatase (CPK) enzymes
الملخص
The paper involves a biological study for the effects of ligand (1,1 – dimethyl -3- (thiazole -2- yl) – triazine) and two from its complexes on enzymes having a role in cancer, bone inflammations and heart diseases, 20 blood samples were collected for patients having bone inflammations, and 20 other blood samples from patients with heart disorders, aged (50-65) years old from Alkomes teaching hospital in Alkomes City, Libya and asses the effectiveness of enzymes Lactate dehydrogenase (LDH), and Creatine phosphatase (CPK). The study of the inhibition of these enzymes was carried out at 0.1, 0.05, 0.025mM concentrations in the blood of patients having bone inflammation. The ligand inhibits CPK by 24% at 0.1mM and 7.8% at 0.05mM, while at 0.025mM it was activated by 8.2%, while the enzyme LDH was inhibited by 18.7% at 0.1mM concentration and 6.9% at 0.05mM.While at 0.025mM activated by 6.5%.The effects of the Cu(II) and Ni complexes studied on these enzymes were that these complexes have greater inhibition effects on these enzymes, the inhibition ranged between 47-72 % in the blood of a patients having bone inflammations, There was an when substrate concentration[S] was increased from (0.01-0.02 mM) and also Cu complex was more inhibited than Ni complex and ligand in the blood of patients having heart diseases.
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