Synthesis and Study of the Physical,Thermal,Chemical,and Biological Properties of 2,4-Dinitrophenylhydrazones of Substituted Chalcones
DOI:
https://doi.org/10.58916/jhas.v10i1.654الكلمات المفتاحية:
Biological activity (anticancer, enzyme inhibition), 2,4-Dinitrophenylhydrazine، Pharmaceutical, Spectroscopic analysis (FT-IR and UV-Vis), Substituted chalcone derivatives.الملخص
This study investigates the synthesis, characterization, and evaluation of the physicochemical and biological properties of 2,4-dinitrophenylhydrazones derived from substituted chalcones. The primary objective is to explore these compounds for their potential applications in pharmaceuticals and material sciences, particularly focusing on their anticancer and antioxidant properties.
The hydrazones were synthesized through a modified condensation reaction between substituted chalcones and 2,4-dinitrophenylhydrazine in an acidic medium under controlled reflux conditions. High-purity crystalline products were obtained and characterized using infrared (IR) and UV-visible spectroscopy. These methods confirmed the successful synthesis and structural integrity of the hydrazones by identifying key functional groups and electronic transitions.
Thermogravimetric analysis was conducted to assess thermal stability, revealing decomposition temperatures exceeding 250°C, which highlights their robustness. UV-visible spectroscopic studies further demonstrated the compounds' solvent-dependent electronic behavior, showcasing a notable bathochromic shift in polar environments, indicative of their adaptability in optoelectronic applications.
Biological activity predictions were performed using PASS Online and molecular docking studies. These analyses revealed significant anticancer activity through strong binding interactions with the Mcl-1 protein and potent antioxidant properties, with predicted probabilities (Pa) exceeding 0.75. Computational tools also suggested potential enzyme inhibition capabilities, broadening their pharmaceutical relevance
In conclusion, this research highlights the versatility of 2,4-dinitrophenylhydrazones, demonstrating their promising applications in drug development and advanced technological fields. The findings establish a foundation for future in vitro and in vivo studies to validate their biological efficacy and explore their practical applications in industrial and pharmaceutical innovations.
التنزيلات
المراجع
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كيفية الاقتباس
