Parkinson's Disease: An Integrative Analysis of Pathophysiology, Genetic Susceptibility, Diagnosis, Therapeutic Strategies, and Emerging Researches
Abstract
Parkinson's disease is a chronic , degenerative and the second most prevalent neurodegenerative disorder, with a wide spectrum of clinical features, caused by a group of interaction factors , mainly , genetic and environmental factors. PD is marked by a progressive decline in dopaminergic neurotransmission in the human midbrain, as well as, aggregation of Lewy bodies. patients with PD can demonstrate a wide array of motor symptoms, including tremor, muscle rigidity, and slowed movements (bradykinesia). Genetic studies of familial forms of PD have revealed rare causative mutations in at least three genes responsible for autosomal recessive inheritance patterns.. The accurate diagnosis of Parkinson's disorder is a vital for prognostic and therapeutic reasons and is essential for all clinical research, moreover, the available medications mainly manage the dopaminergic features of the disease, however, the medications for the management of non-motor symptoms is inadequate. Advances in genotyping technology have paved the way of a high-throughput genome-wide screening of common variants in large populations offering a novel opportunities for the investigating the genetic basis of Parkinson's disease.
Keywords:
Autosomal recessive
Bradykinesia, Dopaminergic Neurotransmission
, Lewy bodies
Parkinson's disease
How to Cite
Ali Abdussalam Khalifa Alshibani. (2025). Parkinson’s Disease: An Integrative Analysis of Pathophysiology, Genetic Susceptibility, Diagnosis, Therapeutic Strategies, and Emerging Researches. Bani Waleed University Journal of Humanities and Applied Sciences, 10(2), 520-536. https://doi.org/10.58916/jhas.v10i2.773
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