KINETICS STUDY OF THE FORMATION OF AZO DYE DERIVED FROM A DRUG (17-(CYCLOPROPYLMETHYL)-4,5Α-EPOXY-3,14-DIHYDROXYMORPHINAN-6-ONE)

الملخص

     Using spectrophotometer at room temperature (290K) at λmax=499nm, we examined the kinetics of the formation reaction between (4-Aminoaniline) and (Luminal) to produce the azo dye(5,5'-((1,4-phenylenebis(diazene-2,1-diyl))bis(4,1-phenylene))bis(5-ethylpyrimidine-2,4,6(1H,3H,5H)-trione)). The aqueous solution of the prepared dye under study, which had a mole-ratio of its components: (1.0Luminal:2.0Azotized(4-Aminoaniline) reagent), was produced under optimal conditions as determined by the electronic spectrometer (UV+Visible) at a concentration of 0.001M for both the reactants and the new produced dye.

     Its formation rate constant peaked at 310K(0.0741) and fell to its lowest value at 280K(0.0375). A tenfold increase in the reagent concentration (5.0ml. of 10^-3M) showed no influence on the reaction rate constant, indicating that the reaction for the synthesis of the produced dye also followed pseudo-first-order kinetics with regard to the luminal concentration. The anticipated time needed to complete the dye creation process was determined, along with the half-life-times of the dye formation reaction at the four temperatures (t_1/2=9.4min. at 310K, t_1/2=11.3min. at 290K, t_1/2=14.2min. at 300K, and t_1/2=18.5min. at 310K).

     It's interesting to see that the latter's values at the four temperatures were inversely related to the reaction's rate constants there. Ultimately, temperature had an impact on the change in the values of(A∞) and the time to completion of the formation reaction(t∞). The new dye is formed more quickly when the half-life-time of this dye formation reaction decrease with temperature. The activation energy value (Ea=4.2J) and frequency factor(A=1.002) decrease, indicating the speed and spontaneity of the formation reaction without the need for catalysts, which is economically viable from an industrial point of view.